From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies

From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies

Author Conrad, K. Google Scholar
Andrade, L. E. C. Autor UNIFESP Google Scholar
Chan, E. K. L. Google Scholar
Mahler, M. Google Scholar
Meroni, P. L. Google Scholar
Pruijn, G. J. M. Google Scholar
Steiner, G. Google Scholar
Shoenfeld, Y. Google Scholar
Abstract Testing for autoantibodies (AABs) is becoming more and more relevant, not only for diagnosing autoimmune diseases (AIDs) but also for the differentiation of defined AID subtypes with different clinical manifestations, course and prognosis as well as the very early diagnosis for adequate management in the context of personalized medicine. A major challenge to improve diagnostic accuracy is to harmonize or even standardize AAB analyses. This review presents the results of the 12th Dresden Symposium on Autoantibodies that focused on several aspects of improving autoimmune diagnostics. Topics that are addressed include the International Consensus on ANA Patterns (ICAP) and the International Autoantibody Standardization (IAS) initiatives, the optimization of diagnostic algorithms, the description and evaluation of novel disease-specific AABs as well as the development and introduction of novel assays into routine diagnostics. This review also highlights important developments of recent years, most notably the improvement in diagnosing and predicting the course of rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, and of autoimmune neurological, gastrointestinal and liver diseases

the potential diagnostic role of anti-DFS70 antibodies and tumor-associated AABs. Furthermore, some hot topics in autoimmunity regarding disease pathogenesis and management are described.
Keywords ANA
autoantibodies
autoimmune diseases
autoimmunity
diagnostics
standardization
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2016
Published in Lupus. London, v. 25, n. 8, p. 787-796, 2016.
ISSN 0961-2033 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 787-796
Origin http://dx.doi.org/10.1177/0961203316644337
Access rights Closed access
Type Article
Web of Science ID WOS:000379238100001
URI https://repositorio.unifesp.br/handle/11600/57679

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