Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

Author Moura, Carolina Foot Gomes de Autor UNIFESP Google Scholar
Ribeiro, Flavia Andressa Pidone Autor UNIFESP Google Scholar
Handan, Bianca Andrade Autor UNIFESP Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Abstract The aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into 3 groups (n = 5), as follows: Control group (non-treated group, CTRL)

Cadmium group (Cd) and grape juice concentrate group (Cd + GJ). Histopathological analysis revealed that liver from animals treated with grape juice concentrate improved tissue degeneration induced by cadmium intoxication. Animals intoxicated with cadmium and treated with grape juice concentrate showed higher cytochrome C gene expression in liver cells. No significant statistically differences (p > 0.05) were found to MMP 2 and 9 immuno-expression between groups. Taken together, our results demonstrate that grape juice concentrate is able to prevent tissue degeneration in rat liver as a result of increasing apoptosis.
Keywords Grape juice concentrate
Cadmium
Rat
Cytochrome C
Metalloproteinases
xmlui.dri2xhtml.METS-1.0.item-coverage Stuttgart
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2016
Published in Drug Research. Stuttgart, v. 66, n. 7, p. 339-344, 2016.
ISSN 2194-9379 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 339-344
Origin https://dx.doi.org/10.1055/s-0035-1569452
Access rights Closed access
Type Article
Web of Science ID WOS:000379389100002
URI https://repositorio.unifesp.br/handle/11600/57673

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