Leflunomide in Takayasu arteritis - A long term observational study

Leflunomide in Takayasu arteritis - A long term observational study

Alternative title Leflunomida na arterite de Takayasu – Estudo observacional de longo prazo
Author Silva de Souza, Alexandre Wagner Autor UNIFESP Google Scholar
Agustinelli, Renan de Almeida Autor UNIFESP Google Scholar
Almeida, Hemerli de Cinque Autor UNIFESP Google Scholar
Oliveira, Patricia Bermudes Autor UNIFESP Google Scholar
Gurgel Pinheiro, Frederico Augusto Autor UNIFESP Google Scholar
Diniz Oliveira, Ana Cecilia Autor UNIFESP Google Scholar
Sato, Emilia Inoue Autor UNIFESP Google Scholar
Abstract Objective: To evaluate the extended follow-up data on efficacy and toxicity of leflunomide therapy in Takayasu arteritis (TA) patients previously enrolled in the original open-label study of short-term effects of leflunomide in TA. Methods: An open-label long-term longitudinal study was performed in TA patients who fulfilled the 1990 American College of Rheumatology criteria for TA and had participated in a previous study that evaluated short-term efficacy of leflunomide in TA. Complete follow-up information could be retrieved from 12 out of 15 patients enrolled in the original study. Disease activity was evaluated by Kerr's criteria and by the Indian Takayasu Activity Score 2010 (ITAS2010). Results: The mean follow up time was 43.0 +/- 7.6 months and 5 (41.6%) TA patients remained on leflunomide therapy while 7 (58.3%) TA patients had to change to another therapy due to failure to prevent relapses in 6 patients and toxicity in one patient. No significant differences were found between patients who remained on leflunomide therapy and those who changed to another agent regarding age at study entry, time since diagnosis, prednisone daily dose at study entry, baseline ITAS2010, mean or maximum ESR and CRP, and cumulative prednisone dose at study end. Among two TA patients who had changed laflunomide to another agent, two had a clinical relapse and needed to change therapy. Conclusion: Leflunomide led to sustained remission in approximately half of patients at a mean time of 12 months and was well tolerated by TA patients. (C) 2016 Elsevier Editora Ltda.
Keywords Systemic vasculitis
Takayasu arteritis
Leflunomide
Therapy
Vasculites sistêmicas
Arterite de Takayasu
Leflunomida
Tratamento
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Portuguese
Date 2016
Published in Revista Brasileira De Reumatologia. New York, v. 56, n. 4, p. 371-375, 2016.
ISSN 0482-5004 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 371-375
Origin http://dx.doi.org/10.1016/j.rbr.2015.09.007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000385039900012
SciELO ID S0482-50042016000400371 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57607

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