F-18-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis

F-18-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis

Alternative title Tomografia por emissão de pósitrons com 18F-fluordesoxiglicose e citocinas séricas e metaloproteinases da matriz na avaliação da atividade da doença na arterite de Takayasu
Author Arraes, Anne E. D. Autor UNIFESP Google Scholar
de Souza, Alexandre W. S. Autor UNIFESP Google Scholar
Mariz, Henrique A. Autor UNIFESP Google Scholar
Silva, Neusa P. Autor UNIFESP Google Scholar
Torres, Ivone C. G. Google Scholar
Pinto, Paula N. V. Google Scholar
Lima, Eduardo N. P. Google Scholar
Sato, Emilia I. Autor UNIFESP Google Scholar
Abstract Objective: To evaluate F-18-fluorodeoxyglucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT)-and serum levels of different cytokines and matrix metalloproteinases (MMPs) in patients with Takayasu's arteritis (TA) and associations with disease activity. Methods: Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-2, IL-6, IL-8, IL-12, IL-18, MMP-3 and MMP-9 were measured in 36 TA patients and 36 controls. Maximum standard uptake value (SUVmax) of 18F-FDG in arterial walls was determined by PET-CT scans. TA patients were classified as active disease, inactive disease and possible active disease. Results: Serum IL-6 and MMP-3 levels were higher in TA patients than in controls (p < 0.001). Serum IL-6 was higher in patients with active disease and in patients with possible active disease than in inactive disease (p < 0.0001). Patients with active disease had higher serum TNF alpha levels than patients with inactive disease (p = 0.049) while patients with possible active disease presented higher IL-18 levels than patients with inactive disease (p = 0.046). Patients with active disease had higher SUVmax values than those with inactive disease (p = 0.042). By ROC curve SUVmax was predictive of active disease in TA and values = 1.3 were associated with disease activity (p = 0.039). Serum TNF-alpha levels were higher in patients with SUVmax = 1.3 than < 1.3 (p = 0.045) and controls (p = 0.012). Serum IL-6 levels were higher in patients with SUVmax = 1.3 than in controls (p < 0.001). No differences regarding other biomarkers were found between TA patients and controls. Conclusions: Higher serum IL-6 and TNF alpha levels as well as higher arterial 18F-FDG uptake are associated with active TA. (C) 2015 Elsevier Editora Ltda.
Keywords Cytokines
Matrix metalloproteinases
Positron emission tomography scan
Takayasu's arteritis
Citocinas
Metaloproteinases da matriz
Tomografia computadorizada
Arterite de Takayasu
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language Portuguese
English
Date 2016
Published in Revista Brasileira De Reumatologia. New York, v. 56, n. 4, p. 299-308, 2016.
ISSN 0482-5004 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 299-308
Origin http://dx.doi.org/10.1016/j.rbr.2015.03.009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000385039900003
SciELO ID S0482-50042016000400299 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57606

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