Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia

Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia

Author Santos, Samile Amorim dos Autor UNIFESP Google Scholar
Silva, Edgar Tavares da Autor UNIFESP Google Scholar
Caris, Aline Venticinque Autor UNIFESP Google Scholar
Lira, Fabio Santos de Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Abstract BackgroundExercise under hypoxic conditions represents an additional stress in relation to exercise in normoxia. Hypoxia induces oxidative stress and inflammation as mediated through tumour necrosis factor (TNF)- release that might be exacerbated through exercise. In addition, vitamin E supplementation might attenuate oxidative stress and inflammation resulting from hypoxia during exercise. The present study aimed to evaluate the effects of vitamin E supplementation (250 mg) on inflammatory parameters and cellular damage after exercise under hypoxia simulating an altitude of 4200 m. MethodsNine volunteers performed three sessions of 60 min of exercise (70% maximal oxygen uptake) interspersed for 1 week under normoxia, hypoxia and hypoxia after vitamin E supplementation 1 h before exercise. Blood was collected before, immediately after and at 1 h after exercise to measure inflammatory parameters and cell damage. ResultsPercentage oxygen saturation of haemoglobin decreased after exercise and recovered 1 h later in the hypoxia + vitamin condition (P < 0.05). Supplementation decreased creatine kinase (CK)-TOTAL, CK-MB and lactate dehydrogenase 1 h after exercise (P < 0.05). The exercise in hypoxia increased interleukin (IL)-6, TNF-, IL-1ra and IL-10 immediately after exercise (P < 0.05). Supplementation reversed the changes observed after exercise in hypoxia without supplementation (P < 0.05). ConclusionsWe conclude that 250 mg of vitamin E supplementation at 1 h before exercise reduces cell damage markers after exercise in hypoxia and changes the concentration of cytokines, suggesting a possible protective effect against inflammation induced by hypoxia during exercise.
Keywords Altitude
Cellular damage
Inflammation
Physical exercise
Supplementation
Vitamin E
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/10917
Date 2016
Published in Journal of Human Nutrition and Dietetics. Hoboken, v. 29, n. 4, p. 516-522, 2016.
ISSN 0952-3871 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 516-522
Origin https://onlinelibrary.wiley.com/doi/full/10.1111/jhn.12361
Access rights Closed access
Type Article
Web of Science ID WOS:000380020400014
URI https://repositorio.unifesp.br/handle/11600/57501

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