The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding

The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding

Author Ochs, Robert L. Google Scholar
Mahler, Michael Google Scholar
Basu, Anamika Google Scholar
Rios-Colon, Leslimar Google Scholar
Sanchez, Tino W. Google Scholar
Andrade, Luis E. Autor UNIFESP Google Scholar
Fritzler, Marvin J. Google Scholar
Casiano, Carlos A. Google Scholar
Abstract Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in clinical laboratory referrals. They target the dense fine speckled autoantigen of 70 kD (DFS70), most commonly known as lens epithelium-derived growth factor p75 (LEDGFp75). Interesting features of these ANAs include their low frequency in patients with systemic autoimmune rheumatic diseases (SARD), elevated prevalence in apparently healthy individuals, IgG isotype, strong trend to occur as the only ANA specificity in serum, and occurrence in moderate to high titers. These autoantibodies have also been detected at varied frequencies in patients with diverse non-SARD inflammatory and malignant conditions such as atopic diseases, asthma, eye diseases, and prostate cancer. These observations have recently stimulated vigorous research on their clinical and biological significance. Some studies have suggested that they are natural, protective antibodies that could serve as biomarkers to exclude a SARD diagnosis. Other studies suggest that they might be pathogenic in certain contexts. The emerging role of DFS70/LEDGFp75 as a stress protein relevant to human acquired immunodeficiency syndrome, cancer, and inflammation also points to the possibility that these autoantibodies could be sensors of cellular stress and inflammation associated with environmental factors. In this comprehensive review, we integrate our current knowledge of the biology of DFS70/LEDGFp75 with the clinical understanding of its autoantibodies in the contexts of health and disease.
Keywords Antinuclear autoantibodies
Autoimmunity
DFS70/LEDGFp75
Inflammation
Stress
xmlui.dri2xhtml.METS-1.0.item-coverage Milan
Language English
Sponsor NIH/NIMHD
NIH/NIMGS
Grant number NIH/NIMHD: P20MD006988
NIH/NIMGS: R25GM060507
Date 2016
Published in Clinical And Experimental Medicine. Milan, v. 16, n. 3, p. 273-293, 2016.
ISSN 1591-8890 (Sherpa/Romeo, impact factor)
Publisher Springer-Verlag Italia Srl
Extent 273-293
Origin http://dx.doi.org/10.1007/s10238-015-0367-0
Access rights Closed access
Type Article
Web of Science ID WOS:000380668500005
URI https://repositorio.unifesp.br/handle/11600/57480

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