Whey protein and albumin effects upon urinary risk factors for stone formation

Whey protein and albumin effects upon urinary risk factors for stone formation

Author Hattori, Camila Mithie Autor UNIFESP Google Scholar
Tiselius, Hans-Goran Google Scholar
Heilberg, Ita Pfeferman Autor UNIFESP Google Scholar
Abstract Protein supplements are consumed for an expected increase in muscle mass and improved exercise performance, but as their impact on lithogenic parameters are unknown, we aimed to evaluate the effects of Whey protein (WP) and Albumin upon the risk factors for nephrolithiasis. WP or Albumin supplements (one scoop/day) were administered for 3 days to 18 healthy volunteers, with 1-week washout period between them. Serum and 24-h urine samples were collected at baseline and after completing each intervention. All participants were asked to replicate their baseline diet during the subsequent urine collection. After WP or albumin, mean protein equivalent of nitrogen appearance (PNA) was significantly higher (p < 0.001), as the result of the consumption of each of the supplements, but mean urinary calcium, phosphorus, sodium, potassium, uric acid, citrate, oxalate, magnesium, creatinine, pH, and urinary saturation indices did not differ from baseline. However, individual increases higher than 50% in urinary calcium were observed in 39% of the individuals and variable decreases in urinary pH in 44 and 67% of them, respectively, after WP or Albumin. Increases higher than 50% in urinary sodium occurred in one-third of them after Albumin. A short-term consumption of WP or albumin by healthy subjects, under controlled diet, did not significantly change the mean lithogenic parameters. Nevertheless, the wide individual variation and relevant increases/decreases observed for urinary calcium, sodium, and pH suggest the need of a closer surveillance of these parameters and adequacy of diet in case of supplementation by stone formers.
Keywords Albumin
Hypercalciuria
Kidney stones
Nephrolithiasis
Whey protein
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Nephrology Division of Universidade Federal de Sao Paulo
Escola Paulista de Medicina and Hospital do Rim
Date 2017
Published in Urolithiasis. New York, v. 45, n. 5, p. 421-428, 2017.
ISSN 2194-7228 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 421-428
Origin http://dx.doi.org/10.1007/s00240-017-0975-0
Access rights Closed access
Type Article
Web of Science ID WOS:000410748000001
URI https://repositorio.unifesp.br/handle/11600/57321

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