The role of sleep in pemphigus: a review of mechanisms and perspectives

The role of sleep in pemphigus: a review of mechanisms and perspectives

Author Pedroni, Matheus Negrao Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Porro, Adriana Maria Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Abstract Pemphigus is an autoimmune bullous disease that causes the development of blisters and erosions on the skin and/or mucosa. Its inflammatory process is mediated by cytokines, which interact with sleep in a bidirectional manner. Pain, a frequent symptom due to pemphigus lesions, is well known to impair sleep quality. Depression is also associated with pemphigus and pro-inflammatory cytokines and may impair sleep. Additionally, a common relationship among other dermatological diseases and sleep has increasingly been described. Poor sleep quality is associated with an increased risk for autoimmune diseases, and insomnia is a comorbidity that has recently been associated with pemphigus. Thus, this review will explore the evidence supporting the likely bidirectional relationship between pemphigus and sleep quality and its possible mechanisms involved. This approach covering both pemphigus and sleep will open a research avenue for future studies focusing on the efficacy of the sleep disorders treatment in patients with pemphigus. In the long term, this may provide relevant information to dermatologists regarding new strategies for the management of pemphigus clinical condition, allowing possibly a better quality of life for the patients.
Keywords Pemphigus
Autoimmunity
Sleep
Dermatology
Cytokines
Pain
Depression
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Grant number FAPESP: 2014/15259-2
FAPESP: 2016/16703-9
Date 2017
Published in Archives Of Dermatological Research. New York, v. 309, n. 8, p. 659-664, 2017.
ISSN 0340-3696 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 659-664
Origin http://dx.doi.org/10.1007/s00403-017-1765-9
Access rights Closed access
Type Article
Web of Science ID WOS:000411335500007
URI https://repositorio.unifesp.br/handle/11600/57307

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