Factors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohort

Factors predictive of high disease activity early in the course of SLE in patients from a Latin-American cohort

Author Pimentel-Quiroz, Victor R. Google Scholar
Ugarte-Gil, Manuel E. Google Scholar
Pons-Estel, Guillermo J. Google Scholar
Soriano, Enrique R. Google Scholar
Saurit, Veronica Google Scholar
Sato, Emilia I. Autor UNIFESP Google Scholar
Lavras Costallat, Lilian T. Google Scholar
Fernando Molina, Jose Google Scholar
Iglesias-Gamarra, Antonio Google Scholar
Reyes-Llerena, Gil Google Scholar
Neira, Oscar J. Google Scholar
Barile, Leonor A. Google Scholar
Silveira, Luis H. Google Scholar
Segami, Maria Ines Google Scholar
Chacon-Diaz, Rosa Google Scholar
Wojdyla, Daniel Google Scholar
Alarcon, Graciela S. Google Scholar
Pons-Estel, Bernardo A. Google Scholar
Abstract Aims: To determine the factors predictive of disease activity early in the course of SLE (baseline visit). Methods: Patients from GLADEL, a multi-national, multi-ethnic, Latin-American lupus cohort were included. Disease activity was evaluated at baseline with the SLEDAI score. Demographic characteristics (age at diagnosis, gender, ethnicity, marital status, educational level, medical coverage and socioeconomic status) were assessed. Disease duration was defined as the time between the fourth ACR criterion and baseline. Time to criteria accrual was defined as the interval between the first and fourth ACR criterion. Use of glucocorticoids was recorded as the highest dose received before the baseline visit. Antimalarials and immunosuppressive drugs were recorded as use or not use. Univariable and multivariable analysis were performed. Model selection was based on backward elimination. Results: One thousand two hundred sixty-eight patients were included

1136 (89.6%) of them were female. Mean age at diagnosis was 29.2 (SD: 12.3) years. Five hundred sixty-five (44.6%) were Mestizo, 539 (42.5%) were Caucasians and 164 (12.9%) were African-Latin-Americans. The mean SLEDAI at baseline was 10.9 (SD: 8.4). Longer time between first and fourth ACR criterion, medical coverage, a dose of prednisone between 15 and 60 mg/d, and the use of antimalarials were factors protective of disease activity, while Mestizo and African-Latin-American ethnicities were predictive factors. Conclusions: Mestizo and African-Latin-American ethnicities were predictive whereas antimalarial use, medical coverage, and longer time to criteria accrual were protective of higher disease activity early in the disease course. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Systemic lupus erythematosus
Disease activity
Antimalarial use
Ethnic group
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Date 2017
Published in Seminars In Arthritis And Rheumatism. Philadelphia, v. 47, n. 2, p. 199-203, 2017.
ISSN 0049-0172 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co-Elsevier Inc
Extent 199-203
Origin http://dx.doi.org/10.1016/j.semarthrit.2017.01.012
Access rights Closed access
Type Article
Web of Science ID WOS:000412382000008
URI https://repositorio.unifesp.br/handle/11600/57301

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