Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic

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dc.contributor.author Martins Mimura, Maria Angela [UNIFESP]
dc.contributor.author Borra, Ricardo Carneiro
dc.contributor.author Watashi Hirata, Cleonice Hitomi [UNIFESP]
dc.contributor.author Penido, Norma de Oliveira [UNIFESP]
dc.date.accessioned 2020-08-04T13:40:06Z
dc.date.available 2020-08-04T13:40:06Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1111/jop.12621
dc.identifier.citation Journal Of Oral Pathology & Medicine. Hoboken, v. 46, n. 9, p. 821-828, 2017.
dc.identifier.issn 0904-2512
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57296
dc.description.abstract Background: There are indications that Th1 polarization of immune response plays an important role in the pathogenesis of recurrent aphthous stomatitis (RAS), and that the use of probiotics can stimulate immune regulatory activity, influencing the course of the disease. The aim of this study was to characterize the initial immune profile of RAS patients and evaluate clinical and serological response following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus, and Bifidobacterium. Methods: The immune responses of the 45 patients with RAS, submitted to symbiotic or placebo for 120 days, in relation to 30 RAS-free controls, were evaluated over a period of 6 months. Peripheral blood was collected from all patients at 0 (T0), 120 (T4), and 180 days (T6) after the start of treatment and Th1 (IL12-p70, IFN-gamma), Th2 (IL-4), Treg (IL-10), Th17 (IL-17A), inflammatory (TNF-alpha, IL-6)-associated cytokines, and clinical parameters were quantified. Results: At T0, significant differences were found in the serological levels of the IFN-gamma, IL-4, and IL-6 cytokines of the RAS patients in comparison with the controls. It was observed that the cytokine profile of the RAS group was comprised of 2 distinct clusters: a pure Th2 and a Mixed (Th1/Th2) subtype and that symbiotic treatment induced an improvement in pain and an increase in IFN-gamma levels, producing a reduction in Th2 response. Conclusions: In RAS, symbiotic treatment based on a fructooligosaccharide, Lactobacillus, and Bifidobacterium composition produced an alteration in the Th2 serological immune profile in the direction of Th1 and improved pain symptomatology. en
dc.description.sponsorship CAPES
dc.description.sponsorship Beneficent Association for Blood Collection (COLSAN)
dc.format.extent 821-828
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Journal Of Oral Pathology & Medicine
dc.rights Acesso restrito
dc.subject cytokines en
dc.subject immunology en
dc.subject recurrent aphthous stomatitis en
dc.subject treatment en
dc.title Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Otorhinolaryngol Head & Neck Surg, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Carlos UFSCAR, Dept Genet & Evolucao, Sao Carlos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Otorhinolaryngol Head & Neck Surg, Escola Paulista Med UNIFESP EPM, Sao Paulo, Brazil
dc.identifier.doi 10.1111/jop.12621
dc.description.source Web of Science
dc.identifier.wos WOS:000412303500025
dc.coverage Hoboken
dc.citation.volume 46
dc.citation.issue 9



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