Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients

Use of the plasma CTX for assessing the bone activity of the mandible among osteopenic and osteoporotic patients

Author Avolio, Glacio Autor UNIFESP Google Scholar
Brandão, Cynthia Autor UNIFESP Google Scholar
Marcucci, Marcelo Autor UNIFESP Google Scholar
Alonso, Gilberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to determine whether the plasma CTX bone remodeling marker is useful for indicating the bone metabolic activity level of the mandible. Thirty-six patients were selected; all were postmenopausal and aged 50 years or over. In accordance with the WHO criteria for osteoporosis, a control group was set up (n = 10) in which the T-score was greater than -1 and a diseased group with T-score less than -1. Using MDP-99mTc samples, the radioisotope uptake in the femoral neck (R2) and mandibular body (R1) was analyzed. A third examination was performed using the plasma CTX biochemical bone-modeling marker. The inferential results for the diseased group showed that Ln(R1) presented a statistically significant linear relationship with Ln(CTx) (p = 0.067) and with the T-score (p = 0.018). The plasma CTX bone remodeling marker is useful for monitoring the bone metabolic activity of the mandible.
Keywords Biological markers
Bone diseases
Mandible
Language English
Date 2010-06-01
Published in Brazilian Oral Research. Sociedade Brasileira de Pesquisa Odontológica - SBPqO, v. 24, n. 2, p. 250-255, 2010.
ISSN 1806-8324 (Sherpa/Romeo)
Publisher Sociedade Brasileira de Pesquisa Odontológica - SBPqO
Extent 250-255
Origin http://dx.doi.org/10.1590/S1806-83242010000200020
Access rights Open access Open Access
Type Article
SciELO ID S1806-83242010000200020 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/5729

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