Otologic manifestations of Larsen syndrome

Otologic manifestations of Larsen syndrome

Author de Sousa Marques, Leticia Helena Google Scholar
Martins, Daniela Vieira Google Scholar
Juares, Gabriel Liria Google Scholar
Moura Lorenzetti, Fabio Tadeu Google Scholar
Monsanto, Rafael da Costa Autor UNIFESP Google Scholar
Abstract Objective: To describe and discuss otologic manifestations of Larsen syndrome, based on a case report and a systematic review of the literature. Materials and methods: We performed a PubMED database search, and we selected studies reporting otolaryngologic manifestations secondary to Larsen syndrome. The selected articles were read in full, and three researchers independently extracted data from the studies. In parallel, we report the case of a 14 year-old patient who had hearing loss secondary to Larsen syndrome. Results: Fifteen studies met our selection criteria. Seven studies reported hearing loss in patients with Larsen syndrome (4 had conductive hearing loss and 3 had mixed hearing loss). The conductive hearing loss may be secondary to ossicular malformations and/or middle ear effusions. Other causes for conductive hearing loss are mesenchymal remnants in the middle ear, Eustachian tube dysfunction, and cleft palate. Surgical management of the hearing loss is possible in selected cases, although the surgical and anesthetic risks should be considered. Hearing aids seem to be safe and effective treatment options for the hearing loss secondary to Larsen syndrome. Conclusion: Although rare, patients with Larsen syndrome may have hearing loss. The most frequent type of deficit is conductive, either secondary to malformation of the ossicles or middle ear effusion. Possible surgical correction of these abnormalities should be weighed against the anesthetic risks of these patients. (C) 2017 Elsevier B.V. All rights reserved.
Keywords Larsen syndrome
Hearing loss
Treatment
Hearing aids
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Date 2017
Published in International Journal Of Pediatric Otorhinolaryngology. Clare, v. 101, p. 223-229, 2017.
ISSN 0165-5876 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 223-229
Origin http://dx.doi.org/10.1016/j.ijporl.2017.08.020
Access rights Closed access
Type Article
Web of Science ID WOS:000413713100038
URI https://repositorio.unifesp.br/handle/11600/57286

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