The Role of Toll Like Receptors (TLRs) in Oral Carcinogenesis

The Role of Toll Like Receptors (TLRs) in Oral Carcinogenesis

Author Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Abstract Oral cancer accounts for 10% of head and neck tumors. Despite the recent advancements in surgical techniques, as well as in chemo-and radiotherapy therapeutic protocols, survival rates for oral cancer patients have not improved significantly in the last decades. Recently, toll like receptors (TLRs) have been described as promoters of cell proliferation, invasiveness, and angiogenesis in a variety of cancers. The aim of this review is to identify how TLRs participate in oral carcinogenesis in order to evaluate their biological relevance. Data revealed that some TLRs participate in oral carcinogenesis since TLR5 and TLR9 promote tumor growh, whereas TLR3 is closely involved to anti-cancer properties. They represent a promising alternative for oral cancer therapy. However, TLR2, TLR4 and TLR7 need further investigation, since current data are not sufficient to conclude about their role. Certainly, such data will contribute to new scientific knowledge, which will be incorporated to the preventive actions and therapeutic protocols for oral cancer patients suffering from this devasting disease.
Keywords Oral cancer
toll like receptors
oral carcinogenesis
oral cancer
xmlui.dri2xhtml.METS-1.0.item-coverage Athens
Language English
Sponsor National Council for Scientific and Technological Development (CNPq)
Date 2017
Published in Anticancer Research. Athens, v. 37, n. 10, p. 5389-5394, 2017.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 5389-5394
Access rights Closed access
Type Article
Web of Science ID WOS:000412584300008

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