Evidence for Involvement of IL-9 and IL-22 in Cows' Milk Allergy in Infants

Evidence for Involvement of IL-9 and IL-22 in Cows' Milk Allergy in Infants

Author Barros, Karina V. Autor UNIFESP Google Scholar
Flor Silveira, Vera L. [UNIFESP Google Scholar
Laranjeira, Marisa S. Google Scholar
Wandalsen, Neusa F. Google Scholar
Passeti, Susana Google Scholar
De Oliveira, Roberta Google Scholar
Munekata, Regina V. Google Scholar
Noakes, Paul S. Google Scholar
Miles, Elizabeth A. Google Scholar
Calder, Philip C. Google Scholar
Abstract Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 +/- 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20). Blood samples were collected before treatment during active disease (T0) and after 120 days, when symptoms were absent (T1). Plasma cytokine concentrations were measured. Infants with CMA had higher plasma concentrations of interleukin (IL)-4 and IL-13 and lower concentrations of IL-9, IL-17A and interferon-gamma, compared with healthy breast-fed infants. At T0, there was a positive correlation between blood eosinophil numbers and plasma concentrations of IL-4, IL-9, IL-17A and IL-22. Treatment with a cows' milk elimination diet resulted in a decrease in plasma IL-4, IL-9, IL-13 and IL-22 and an increase in plasma IL-17A. We conclude that IL-4 and IL-13 are elevated in active CMA. The association of IL-9 and IL-22 with eosinophilia, and the decrease in these two cytokines with cows' milk elimination, suggests that they both play a role in the symptoms observed in CMA and may be important targets for future interventions.
Keywords cows' milk allergy
cytokine
dietetic treatment
hydrolysed soy formula
free amino acid formula
xmlui.dri2xhtml.METS-1.0.item-coverage Basel
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
Date 2017
Published in Nutrients. Basel, v. 9, n. 10, p. -, 2017.
ISSN 2072-6643 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent -
Origin http://dx.doi.org/10.3390/nu9101048
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000414629900004
URI https://repositorio.unifesp.br/handle/11600/57235

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