The Effect of Citalopram Versus a Placebo on Central Auditory Processing in the Elderly

The Effect of Citalopram Versus a Placebo on Central Auditory Processing in the Elderly

Author Polanski, Jose Fernando Autor UNIFESP Google Scholar
Soares, Alexandra Dezani Autor UNIFESP Google Scholar
Pereira, Liliane Desgualdo Autor UNIFESP Google Scholar
de Mendonca Cruz, Oswaldo Laercio Autor UNIFESP Google Scholar
Abstract Objective: Evaluate the effects of therapy with citalopram on the central auditory processing in the elderly measured by central auditory tests. Study Design: Prospective, randomized, double-blind, placebo-controlled study. Setting: Tertiary referral center. Patients: Thirty-nine patients older than 60 years with normal hearing thresholds or symmetrical sensorineural hearing loss up to 70 dBHL, word-recognition score equal to or better than 70%, and diagnosed with central auditory processing disorders completed the study. They underwent the mini-mental state examination, as a way to screen those with the possibility of dementia

they also underwent the Beck depression inventory, for screening individuals with depression. Intervention: Citalopram 20 mg/d or placebo for 6 months. Main Outcome Measure: The central auditory tests were applied to the selection of individuals with auditory processing disorders and repeated after 6 months' treatment. The tests were sound localization, speech in noise, dichotic digits test, pitch pattern sequence, duration pattern test, and gaps-innoise. Results: Comparisons of central auditory tests pre- and posttreatment in groups showed: sound localization (p = 0.022), pitch pattern sequence humming (p = 0.110), pitch pattern sequence nomination (p = 0.355), duration pattern test humming (p = 0.801), duration pattern test nomination (p = 0.614), and gaps-in-noise (p = 0.230). Dichotic tests in right and left ears respectively: speech in noise (p = 0.949

p = 0.722), dichotic digits test (p = 0.943

p = 0.513). Conclusion: There was no clinical effect with the use of citalopram in central auditory processing tests of the subjects.
Keywords Aged
Auditory perceptual disorders
Hearing disorders
Serotonin uptake inhibitors
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Date 2017
Published in Otology & Neurotology. Philadelphia, v. 38, n. 9, p. 1233-1239, 2017.
ISSN 1531-7129 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1233-1239
Access rights Closed access
Type Article
Web of Science ID WOS:000418475600015

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