Description and evaluation of experimental models for uterine transplantation in pigs

Description and evaluation of experimental models for uterine transplantation in pigs

Alternative title Descrição e avaliação de modelos experimentais para transplante uterino em suínos
Author de Oliveira, Emerson Google Scholar
da Silva Tavares, Kelly Alessandra Google Scholar
Vieira Gomes, Mariano Tamura Google Scholar
Salzedas-Netto, Alcides Augusto Autor UNIFESP Google Scholar
Ferreira Sartori, Marair Gracio Autor UNIFESP Google Scholar
Castro, Rodrigo Aquino Autor UNIFESP Google Scholar
Fernandes, Cesar Eduardo Google Scholar
Batista Castello Girao, Manoel Joao Autor UNIFESP Google Scholar
Abstract Objective: To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression. Methods: We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood incompatibility. Hysterectomy was performed in the donor under general anesthesia, with the removal of the aorta and inferior vena cava in monobloc, and anastomosis of these vessels was made in the recipient. Results: Six experiments were performed, and on the immediate postoperative period, five animals had good reperfusion. However, on the seventh postoperative day, histological analysis showed rejection in five animals. Conclusion: The experimental model of uterine transplantation is feasible, but monitoring doses of immunosuppressants is pivotal to prevent rejection episodes.

Objetivo: Avaliar a técnica de transplante uterino e o uso de drogas no processo de imunossupressão. Métodos: Foram incluídas 12 porcas, sendo realizada imunossupressão com doses mínimas de ciclosporina, e prova cruzada para afastar a possibilidade de incompatibilidade sanguínea. Realizou-se, na doadora, histerectomia sob anestesia geral, com a retirada, em monobloco, da aorta e da veia cava inferior, de tal forma que, na receptora, fosse possível realizar a anastomose com estes vasos. Resultados: Foram realizados seis experimentos e, no pós-operatório imediato, houve boa reperfusão em cinco animais. Entretanto, no sétimo dia de pós-operatório, as análises histológicas demonstraram rejeição em cinco deles. Conclusão: O modelo experimental de transplante uterino é factível, mas a monitorização das doses de imunossupressores é importante, a fim de impedir os episódios de rejeição.
Keywords Transplantation
Uterus/transplantation
Infertility
Pregnancy
Swine
Models
animal
Immunosuppressive agents
Cyclosporine
Transplante
Útero/transplante
Infertilidade
Gravidez
Suínos
Modelos animais
Imunossupressores
Ciclosporina
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Portuguese
Sponsor Fundacao de Amparo a Pesquisa de Estado de Sao Paulo (FAPESP)
Grant number FAPESP: 2008/09441-1
Date 2017
Published in Einstein-Sao Paulo. Sao Paulo Sp, v. 15, n. 4, p. 481-485, 2017.
ISSN 1679-4508 (Sherpa/Romeo, impact factor)
Publisher Inst Israelita Ensino & Pesquisa Albert Einstein
Extent 481-485
Origin http://dx.doi.org/10.1590/S1679-45082017AO4066
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000423856800017
SciELO ID S1679-45082017000400481 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57176

Show full item record




File

Name: S1679-45082017000400481-en.pdf
Size: 416.7Kb
Format: PDF
Description:
Open file
Name: S1679-45082017000400481-pt.pdf
Size: 423.4Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account