Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne

Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne

Author Rocha, Marco A. D. Autor UNIFESP Google Scholar
Guadanhim, Lilia R. S. Autor UNIFESP Google Scholar
Sanudo, Adriana Autor UNIFESP Google Scholar
Bagatin, Edileia Autor UNIFESP Google Scholar
Abstract Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. Propionibacterium acnes is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the NF kappa B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Two treatments were performed over six months: 15% azelaic acid gel (AA) bid (n = 18) and oral contraceptive (COC) drospirenone 3 mg/ethinylestradiol .02 mg (n = 20). Biopsies were taken at baseline (control, lesion, perilesional) and at the conclusion (lesion and perilesional) of the study to evaluate TLR-2 expression by immunohistochemistry. Lesion count and blind photographic evaluation were used for efficacy. The groups were homogeneous: 70% of lesions were located in the submandibular area, 95% of participants had inflammatory lesions

of these, 50% had persistent and 50% had late-onset acne. The mean ages were 33.7 +/- 5.5 and 33.1 +/- 5.3 years (COC and AA group, respectively). A moderate clinical improvement was observed in both groups. No difference in TLR-2 expression in the lesion or perilesional areas was observed

however, reduced TLR-2 expression was seen in the control group. A significant reduction in expression was observed after both treatments, with no difference between the groups. This finding suggests an anti-inflammatory effect of COCs and AA in adult female acne, via modulation of the TLR-2 receptor.
Keywords Acne
toll-like receptor 2
combined oral contraceptive
azelaic acid
sebaceous glands
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Dermatology - Sao Paulo Regional of Brazilian
Society of Dermatology - FUNADERSP
Date 2017
Published in Dermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
ISSN 1938-1972 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Inc
Extent -
Origin http://dx.doi.org/10.1080/19381980.2017.1361570
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000428315000001
URI https://repositorio.unifesp.br/handle/11600/57160

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