Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

Author Mackay, Alan Google Scholar
Burford, Anna Google Scholar
Carvalho, Diana Google Scholar
Izquierdo, Elisa Google Scholar
Fazal-Salom, Janat Google Scholar
Taylor, Kathryn R. Google Scholar
Bjerke, Lynn Google Scholar
Clarke, Matthew Google Scholar
Vinci, Mara Google Scholar
Nandhabalan, Meera Google Scholar
Temelso, Sara Google Scholar
Popov, Sergey Google Scholar
Molinari, Valeria Google Scholar
Raman, Pichai Google Scholar
Waanders, Angela J. Google Scholar
Han, Harry J. Google Scholar
Gupta, Saumya Google Scholar
Marshall, Lynley Google Scholar
Zacharoulis, Stergios Google Scholar
Vaidya, Sucheta Google Scholar
Mandeville, Henry C. Google Scholar
Bridges, Leslie R. Google Scholar
Martin, Andrew J. Google Scholar
Al-Sarraj, Safa Google Scholar
Chandler, Christopher Google Scholar
Ng, Ho-Keung Google Scholar
Li, Xingang Google Scholar
Mu, Kun Google Scholar
Trabelsi, Saoussen Google Scholar
H'mida-Ben Brahim, Dorra Google Scholar
Kisljakov, Alexei N. Google Scholar
Konovalov, Dmitry M. Google Scholar
Moore, Andrew S. Google Scholar
Montero Carcaboso, Angel Google Scholar
Sunol, Mariona Google Scholar
de Torres, Carmen Google Scholar
Cruz, Ofelia Google Scholar
Mora, Jaume Google Scholar
Shats, Ludmila I. Google Scholar
Stavale, Joao N. Autor UNIFESP Google Scholar
Bidinotto, Lucas T. Google Scholar
Reis, Rui M. Google Scholar
Entz-Werle, Natacha Google Scholar
Farrell, Michael Google Scholar
Cryan, Jane Google Scholar
Crimmins, Darach Google Scholar
Caird, John Google Scholar
Pears, Jane Google Scholar
Monje, Michelle Google Scholar
Debily, Marie-Anne Google Scholar
Castel, David Google Scholar
Grill, Jacques Google Scholar
Hawkins, Cynthia Google Scholar
Nikbakht, Hamid Google Scholar
Jabado, Nada Google Scholar
Baker, Suzanne J. Google Scholar
Pfister, Stefan M. Google Scholar
Jones, David T. W. Google Scholar
Fouladi, Maryam Google Scholar
von Bueren, Andre O. Google Scholar
Baudis, Michael Google Scholar
Resnick, Adam Google Scholar
Jones, Chris Google Scholar
Abstract We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of > 1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.
xmlui.dri2xhtml.METS-1.0.item-coverage Cambridge
Language English
Sponsor Cancer Research UK
CRIS Cancer Foundation
Abbie's Army
DIPG Collaborative
Cure Starts Now Foundation
McKenna Claire Foundation
Lyla Nsouli Foundation
National Institutes of Health
Dragon Master Foundation
Kortney Rose Foundation
Musella Foundation For Brain Tumor Research Information
Gray Matters Foundation
Pediatric Brain Tumor Foundation
INSTINCT network - Brain Tumour Charity
Great Ormond Street Children's Charity
Children with Cancer UK
NHS
ICR
Sao Paulo Research Foundation
Christopher's Smile
Grant number FAPESP: 2011/08523-7
FAPESP: 2012/08287-4
Date 2017
Published in Cancer Cell. Cambridge, v. 32, n. 4, p. 520-+, 2017.
ISSN 1535-6108 (Sherpa/Romeo, impact factor)
Publisher Cell Press
Extent 520-+
Origin http://dx.doi.org/10.1016/j.ccell.2017.08.017
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000412566900014
URI https://repositorio.unifesp.br/handle/11600/57157

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