Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial

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dc.contributor.author Kamamoto, C. S. L. [UNIFESP]
dc.contributor.author Nishikaku, A. S. [UNIFESP]
dc.contributor.author Gompertz, O. F. [UNIFESP]
dc.contributor.author Melo, A. S. [UNIFESP]
dc.contributor.author Hassun, K. M. [UNIFESP]
dc.contributor.author Bagatin, E. [UNIFESP]
dc.date.accessioned 2020-08-04T13:39:48Z
dc.date.available 2020-08-04T13:39:48Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1080/19381980.2017.1361573
dc.identifier.citation Dermato-Endocrinology. Philadelphia, v. 9, n. 1, p. -, 2017.
dc.identifier.issn 1938-1972
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57132
dc.description.abstract Malassezia spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses antiinflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genotypic identification of Malassezia species before and after low-dose oral isotretinoin or topical antifungal treatments for moderate to severe seborrhea and/or seborrheic dermatitis on scalp. Scales and sebum of the scalp were seeded in the middle of modified Dixon and incubated at 32 degrees C. For genotypic identification polymerase chain reaction primers for the ITS and D1/D2 ribossomal DNA were used and followed by samples sequencing. The procedure was conducted before and after therapeutic and randomized intervention for moderate to severe seborrhea/seborrheic dermatitis on the scalp, including oral isotretinoin, 10 mg, every other day and anti-seborrheic shampoo (piroctone olamine), over six months. The M. globosa and M. restricta were the most frequent species isolated on the scalp before and after both treatments. Other non-Malassezia species were also identified. The Malassezia spp. were maintained in the scalp after both treatments that were equally effective for the control of seborrhea/seborrheic dermatitis clinical signs. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation [FAPESP]), Brazil
dc.format.extent -
dc.language.iso eng
dc.publisher Taylor & Francis Inc
dc.relation.ispartof Dermato-Endocrinology
dc.rights Acesso aberto
dc.subject Malassezia en
dc.subject oral isotretinoin en
dc.subject piroctone olamine en
dc.subject polymerase chain reaction en
dc.subject seborrheic dermatitis en
dc.title Cutaneous fungal microbiome: Malassezia yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial en
dc.type Artigo
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, Brazil
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Dept Med, Special Mycol Lab, Sao Paulo, SP, Brazil
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo UNIFESP, Dept Med, Special Mycol Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2010/51049-1
dc.identifier.file WOS000428316900001.pdf
dc.identifier.doi 10.1080/19381980.2017.1361573
dc.description.source Web of Science
dc.identifier.wos WOS:000428316900001
dc.coverage Philadelphia
dc.citation.volume 9
dc.citation.issue 1



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