The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases

The Underexploited Role of Non-Coding RNAs in Lysosomal Storage Diseases

Author Queiroz, Matheus Trovao de Autor UNIFESP Google Scholar
Pereira, Vanessa Goncalves Autor UNIFESP Google Scholar
Nascimento, Cinthia Castro do Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Abstract Non-coding RNAs (ncRNAs) are a functional class of RNA involved in the regulation of several cellular processes which may modulate disease onset, progression, and prognosis. Lysosomal storage diseases (LSD) are a group of rare disorders caused by mutations of genes encoding specific hydrolases or non-enzymatic proteins, characterized by a wide spectrum of manifestations. The alteration of ncRNA levels is well established in several human diseases such as cancer and auto-immune disorders

however, there is a lack of information focused on the role of ncRNA in rare diseases. Recent reports related to changes in ncRNA expression and its consequences on LSD physiopathology show us the importance to keep advancing in this field. This article will summarize recent findings and provide key points for further studies on LSD and ncRNA association.
Keywords non-coding RNA
lysosomal storage disease
lysosome
miRNA
siRNA
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Instituto de Genetica e Erros Inatos do Metabolismo (IGEIM)
Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Grant number FAPESP: 2014/14230-0
FAPESP: 2015/053818
Date 2016
Published in Frontiers In Endocrinology. Lausanne, v. 7, p. -, 2016.
ISSN 1664-2392 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fendo.2016.00133
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000385361700001
URI https://repositorio.unifesp.br/handle/11600/57100

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