Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Author Peres, Fernanda Fiel Autor UNIFESP Google Scholar
Leyin, Raquel Autor UNIFESP Google Scholar
Suiama, Mayra Akimi Autor UNIFESP Google Scholar
Diana, Mariana Cepollaro Autor UNIFESP Google Scholar
Gouvea, Douglas Albuquerque Autor UNIFESP Google Scholar
Almeida, Valeria Autor UNIFESP Google Scholar
Santos, Camila Mauricio Autor UNIFESP Google Scholar
Lungato, Lisandro Autor UNIFESP Google Scholar
Zuardi, Antonio W. Google Scholar
Hallak, Jaime E. C. Google Scholar
Crippa, Jose A. Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Silva, Regina Helena da Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Abstract Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson's disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2-5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals' performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson's disease and tardive dyskinesia.
Keywords reserpine
cannabidiol
Parkinson's disease
tardive dyskinesia
schizophrenia
rat
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2010/07994-3
FAPESP: 2015/03354-3
CNPq/MS/SCTIE/DECIT: 26/2014
CNPq/MS/SCTIE/DECIT: 466805/2014-4
Date 2016
Published in Frontiers In Pharmacology. Lausanne, v. 7, p. -, 2016.
ISSN 1663-9812 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fphar.2016.00343
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000384265900001
URI https://repositorio.unifesp.br/handle/11600/57099

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