Activation of the Wnt/beta-catenin pathway in pancreatic beta cells during the compensatory islet hyperplasia in prediabetic mice

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dc.contributor.author Maschio, D. A.
dc.contributor.author Oliveira, R. B.
dc.contributor.author Santos, M. R.
dc.contributor.author Carvalho, Carolina Prado de França [UNIFESP]
dc.contributor.author Barbosa-Sampaio, H. C. L.
dc.contributor.author Collares-Buzato, C. B.
dc.date.accessioned 2020-07-31T12:47:48Z
dc.date.available 2020-07-31T12:47:48Z
dc.date.issued 2016
dc.identifier https://dx.doi.org/10.1016/j.bbrc.2016.08.146
dc.identifier.citation Biochemical and Biophysical Research Communications. San Diego, v. 478, n. 4, p. 1534-1540, 2016.
dc.identifier.issn 0006-291X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57096
dc.description.abstract The Wnt/beta-catenin signaling pathway, also known as the canonical Wnt pathway, plays a role in cell proliferation and differentiation in several tissues/organs. It has been recently described in humans a relationship between type 2 diabetes (T2DM) and mutation in the gene encoding the transcription factor TCF7L2 associated to the Wnt/beta-catenin pathway. In the present study, we demonstrated that hyper plastic pancreatic islets from prediabetic mice fed a high-fat diet (HFD) for 60 d displayed nuclear translocation of active p-catenin associated with significant increases in protein content and gene expression of beta-catenin as well as of cyclins Dl, D2 and c-Myc (target genes of the Wnt pathway) but not of Tcf7I2 (the transcription factor). Meanwhile, these alterations were not observed in pancreatic islets from 30 d HFD-fed mice, that do not display significant beta cell hyperplasia. These data suggest that the Wnt/beta-catenin pathway is activated in pancreatic islets during prediabetes and may play a role in the induction of the compensatory beta cell hyperplasia observed at early phase of T2DM. (C) 2016 Published by Elsevier Inc. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundo de Apoio ao Ensino, Pesquisa e Extensão (FAEPEX)/UNICAMP
dc.format.extent 1534-1540
dc.language.iso eng
dc.publisher Academic Press Inc Elsevier Science
dc.relation.ispartof Biochemical and Biophysical Research Communications
dc.rights Acesso restrito
dc.subject Wnt/beta-catenin pathway en
dc.subject Prediabetes en
dc.subject Compensatory beta cell hyperplasia en
dc.title Activation of the Wnt/beta-catenin pathway in pancreatic beta cells during the compensatory islet hyperplasia in prediabetic mice en
dc.type Artigo
dc.description.affiliation Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil
dc.description.affiliation Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.sponsorshipID FAPESP: 2015/25442-1
dc.description.sponsorshipID CNPq: 304991/2015-15
dc.identifier.doi 10.1016/j.bbrc.2016.08.146
dc.description.source Web of Science
dc.identifier.wos WOS:000384390200008
dc.coverage San Diego
dc.citation.volume 478
dc.citation.issue 4



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