Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice

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dc.contributor.author Yujra, Veronica Quispe [UNIFESP]
dc.contributor.author Moretti, Eduardo Gregolin [UNIFESP]
dc.contributor.author Claudio, Samuel Rangel [UNIFESP]
dc.contributor.author Dias Silva, Marcelo Jose
dc.contributor.author Oliveira, Flavia de [UNIFESP]
dc.contributor.author Oshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2020-07-31T12:47:47Z
dc.date.available 2020-07-31T12:47:47Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.3109/01480545.2015.1126843
dc.identifier.citation Drug And Chemical Toxicology. Abingdon, v. 39, n. 4, p. 388-391, 2016.
dc.identifier.issn 0148-0545
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57088
dc.description.abstract Context: Crack cocaine is an illicit drug derived from cocaine, in which use and abuse have increased around the world, especially in developing countries. Objectives: The aim of this study was to evaluate genomic damage in multiple organs of mice following acute exposure to crack cocaine. For this purpose, single cell gel (comet) assay in peripheral blood, liver, kidney, and brain cells was performed and micronucleus test for bone narrow and liver cells was also made in this setting. Material and methods: A total of 20 C57BL/10 male mice were distributed into four groups, as follows: 0, 4.5, 9, and 18mg/kg b.w. of crack cocaine dissolved to 1% dimethyl sulfoxide by intraperitoneal (i.p.) route. All animals were sacrificed 24h after i.p. injection. Results: The results showed that crack cocaine induced DNA damage in peripheral blood, and brain cells for higher doses used as depicted by single cell gel (comet) assay data. Analysis of kidney cells showed no genetic damage for all groups tested. The number of micronucleated cells did not increase after crack cocaine exposure in bone narrow or liver cells. Conclusion: In summary, crack cocaine is a genotoxic agent in peripheral blood, liver, and brain cells but not mutagenic in multiple organs of mice. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 388-391
dc.language.iso eng
dc.publisher Taylor & Francis Ltd
dc.relation.ispartof Drug And Chemical Toxicology
dc.rights Acesso restrito
dc.subject 50-36-2 en
dc.subject crack cocaine en
dc.subject DNA damage en
dc.subject mice en
dc.title Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliation Sao Paulo State Univ, UNESP, Campus Litoral Paulista, Sao Vicente, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo (UNIFESP), Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo (UNIFESP), Dept Biosci, Sao Paulo, SP, Brazil
dc.identifier.doi 10.3109/01480545.2015.1126843
dc.description.source Web of Science
dc.identifier.wos WOS:000381357000006
dc.coverage Abingdon
dc.citation.volume 39
dc.citation.issue 4



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