Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

Author Morandim-Giannetti, Andreia de Araujo Google Scholar
Silva, Rosianne Cristina Google Scholar
Magalhaes Junior, Octaviano Autor UNIFESP Google Scholar
Schor, Paulo Autor UNIFESP Google Scholar
Bersanetti, Patricia Alessandra Autor UNIFESP Google Scholar
Abstract Hydrogels are polymeric materials with numerous medical and biological applications because of their physicochemical properties. In this context, the conditions were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP). The concentration of PVA (X-1), PVA/STMP ratio (X-2), and initial pH (X-3) were modified, and their effect was analyzed in terms of the refractive index (Y-1), density (Y-2), dynamic viscosity (Y-3), and final pH (Y-4). The results demonstrated that X-1 interferes with Y-1, Y-2, and Y-3, and X-2 interferes with Y-2 and Y-3. The best condition for obtaining a hydrogel with characteristics similar to the vitreous humor was 4.2586% PVA (wt/wt), STMP/PVA ratio of 1:6.8213 (wt/wt), and initial pH of 9.424. DSC, ATR-FTIR, swelling degree, and AFM analysis confirmed the PVA reticulation with STMP. Furthermore, STMP increased the glass transition temperature and decreased the water uptake of approximate to 50% of the hydrogels, which can be explained by the crosslinking of PVA chains. Infrared spectroscopy revealed a decrease of hydroxyl bonds and confirmed the reticulation between PVA and STMP. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1386-1395, 2016.
Keywords hydrogel
crosslinking
polyvinylalcohol
vitreous substitute
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
University Center of FEI, Department of Ophthalmology and Visual Sciences of the Federal University of Sao Paulo (UNIFESP)
Grant number FAPESP: 2012/07343-8
Date 2016
Published in Journal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 104, n. 7, p. 1386-1395, 2016.
ISSN 1552-4973 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1386-1395
Origin http://dx.doi.org/10.1002/jbm.b.33473
Access rights Closed access
Type Article
Web of Science ID WOS:000383773400013
URI https://repositorio.unifesp.br/handle/11600/57034

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account