Enhanced liver fibrosis (ELF) score: Analytical performance and distribution range in a large cohort of blood donors

Enhanced liver fibrosis (ELF) score: Analytical performance and distribution range in a large cohort of blood donors

Author Dellavance, Alessandra Google Scholar
Fernandes, Flavia Google Scholar
Shimabokuro, Natalia Autor UNIFESP Google Scholar
Latini, Flavia Google Scholar
Baldo, Danielle Google Scholar
Barreto, Jose Augusto Google Scholar
Marvulle, Valdecir Autor UNIFESP Google Scholar
Andrade, Luis Eduardo Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Autor UNIFESP Google Scholar
Abstract Background: The Enhanced Liver Fibrosis (ELF) is a serological score that includes hyaluronic acid (HA), tissue inhibitor of matrix metalloproteinases-1(TIMP-1), and aminoterminal propeptide of type III procollagen (PIIINP) and shows good performance for detecting liver fibrosis. There are few studies evaluating ELF's intra and inter assay variation and stability of the samples. The influence of host variables, such as age, gender and body mass index (BMI) is also not well known. We determined ELF's analytical performance and possible influences of gender, age and BMI. Methods: The study included 958 healthy blood donors evaluated for age, gender, and BMI. Results: Mean ELF scores were significantly different between female (8.53 +/- 0.75) and male groups (8.76 +/- 0.76) and also according to age strata (p < 0.001). For both genders, ELF significantly varied in individuals with BMI under 25 (p < 0.001). Analytes remained stable after freezing/thawing cycles and intra- and inter-assay coefficients of variation were low. Conclusions: ELF has appropriate precision and is quite robust, due to the high stability of the analytes in fresh and frozen samples. ELF's results are influenced by gender, age and BMI which should be taken into account when analyzing its results. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Elf
Coefficient of variation
Liver fibrosis
Hyaluronic acid
Metalloproteinases
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Date 2016
Published in Clinica Chimica Acta. Amsterdam, v. 461, p. 151-155, 2016.
ISSN 0009-8981 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 151-155
Origin http://dx.doi.org/10.1016/j.cca.2016.08.006
Access rights Closed access
Type Article
Web of Science ID WOS:000383944000025
URI https://repositorio.unifesp.br/handle/11600/57031

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