Assessment of Early Treatment Response With DWI After CT-Guided Radiofrequency Ablation of Functioning Adrenal Adenomas

Assessment of Early Treatment Response With DWI After CT-Guided Radiofrequency Ablation of Functioning Adrenal Adenomas

Author Nunes, Thiago Franchi Autor UNIFESP Google Scholar
Szejnfeld, Denis Autor UNIFESP Google Scholar
Szejnfeld, Jacob Autor UNIFESP Google Scholar
Kater, Claudio Elias Autor UNIFESP Google Scholar
Faintuch, Salomao Google Scholar
Castro, Charlles Heldan de Moura Autor UNIFESP Google Scholar
Goldman, Suzan Menasce Autor UNIFESP Google Scholar
Abstract OBJECTIVE. The objective of this study was to establish the suitability of the apparent diffusion coefficient (ADC) as a parameter for evaluating early treatment response after percutaneous ablation of functional adrenal adenomas. SUBJECTS AND METHODS. Seventeen adult patients with functioning adrenal adenomas underwent radiofrequency ablation. Serum hormone levels were analyzed before and up to 6 months after ablation. MRI findings (nodule size in cm, signal intensity index, ADC maps, and nodule-to-muscle ADC ratio) were analyzed before and up to 30 days after ablation. A consensus review of all scans was performed by two attending abdominal imaging radiologists. The procedure was considered successful if serum hormone levels normalized and no contrast enhancement of the adrenal lesion was seen on follow-up MRI. RESULTS. Of 17 patients who underwent radiofrequency ablation, complete response was achieved in 16 patients with partial response in one patient. Of the four parameters of interest, only ADC maps and nodule-to-muscle ADC ratio showed statistically significant differences (p < 0.05). CONCLUSION. This prospective study suggests that apparent diffusion coefficient values may help radiologists monitor early treatment response after CT-guided radiofrequency ablation of functioning adrenal adenomas.
Keywords ablation radiofrequency
ablation techniques
MRI
xmlui.dri2xhtml.METS-1.0.item-coverage Reston
Language English
Date 2016
Published in American Journal Of Roentgenology. Reston, v. 207, n. 4, p. 804-810, 2016.
ISSN 0361-803X (Sherpa/Romeo, impact factor)
Publisher Amer Roentgen Ray Soc
Extent 804-810
Origin http://dx.doi.org/10.2214/AJR.16.16207
Access rights Closed access
Type Article
Web of Science ID WOS:000384568100028
URI https://repositorio.unifesp.br/handle/11600/57016

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