Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model

Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model

Author Santos, Camila Mauricio Autor UNIFESP Google Scholar
Peres, Fernanda Fiel Autor UNIFESP Google Scholar
Diana, Mariana Cepollaro Autor UNIFESP Google Scholar
Justi, Veronica Autor UNIFESP Google Scholar
Suiama, Mayra Akimi Autor UNIFESP Google Scholar
Santana, Marcela Goncalves Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Abstract Schizophrenia is a highly disabling mental disorder, in which genetics and environmental factors interact culminating in the disease. The treatment of negative symptoms and cognitive deficits with antipsychotics is currently inefficient and is an important field of research. Environmental enrichment (EE) has been suggested to improve some cognitive deficits in animal models of various psychiatric disorders. In this study, we aimed to evaluate a possible beneficial effect of early and long-term exposure to EE on an animal model of schizophrenia, the SHR strain. Young male Wistar rats (control strain) and SHRs (21 post-natal days) were housed for 6 weeks in two different conditions: in large cages (10 animals per cage) containing objects of different textures, forms, colors and materials that were changed 3 times/week (EE condition) or in standard cages (5 animals per cage - Control condition). Behavioral evaluations - social interaction (SI), locomotion, prepulse inhibition of startle (PPI) and spontaneous alternation (SA) - were performed 6 weeks after the end of EE. SHRs presented deficits in PPI (a sensorimotor impairment), SI (mimicking the negative symptoms) and SA (a working memory deficit), and also hyperlocomotion (modeling the positive symptoms). EE was able to reduce locomotion and increase PPI in both strains, and to prevent the working memory deficit in SHRs. EE also increased the number of neurons in the CA1 and CA3 of the hippocampus. In conclusion, EE can be a potential nonpharmacological strategy to prevent some behavioral deficits associated with schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Schizophrenia
Animal model
Environmental enrichment
Spontaneous alternation
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2011/18851-1
FAPESP: 2011/50740-5
CNPq: 308241/2016-6
Date 2016
Published in Schizophrenia Research. Amsterdam, v. 176, n. 43526, p. 552-559, 2016.
ISSN 0920-9964 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 552-559
Access rights Closed access
Type Article
Web of Science ID WOS:000384130200074

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