Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

Author Souza, Paulo Victor Sgobbi de Autor UNIFESP Google Scholar
Pinto, Wladimir Bocca Vieira de Rezende Autor UNIFESP Google Scholar
Rezende Filho, Flavio Moura Autor UNIFESP Google Scholar
Oliveira, Acary Souza Bulle Autor UNIFESP Google Scholar
Abstract Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
Keywords motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Date 2016
Published in Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 10, p. 849-854, 2016.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos Neuro- Psiquiatria
Extent 849-854
Origin http://dx.doi.org/10.1590/0004-282X20160117
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000386578100013
SciELO ID S0004-282X2016001000849 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56975

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