Neurocognitive function in patients with residual excessive sleepiness from obstructive sleep apnea: a prospective, controlled study

Neurocognitive function in patients with residual excessive sleepiness from obstructive sleep apnea: a prospective, controlled study

Author Werli, Ksdy Sousa Autor UNIFESP Google Scholar
Otuyama, Leonardo Jun Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Rizzi, Camila Furtado Autor UNIFESP Google Scholar
Guilleminault, Christian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Abstract Objective: This study aimed to evaluate neurocognitive function in adult patients with residual excessive sleepiness (RES) after appropriate treatment of obstructive sleep apnea (OSA) with CPAP and good adherence to treatment. Methods: This was a prospective controlled study. We included patients of both sexes, aged 35-60 years with OSA and an apnea-hypopnea index>20 ev/h, effectively treated with CPAP, but with a residual Epworth Sleepiness Scale score >= 11. The control group consisted of OSA patients adequately treated with CPAP who did not present with excessive sleepiness after treatment. Both groups underwent the following evaluations: polysomnography, multiple sleep latency testing, depression symptoms, and cognitive assessment. Results: Regarding baseline characteristics, the data were matched for age, years of study, and body mass index. Long-term memory result did not show a significant difference between the two groups (RES group 4.7 +/- 2.0

control group 6.5 +/- 1.9

p = 0.08). The executive functions were the most affected, with alterations in Wisconsin test, number of categories (RES group: 1.6 +/- 1.4

control group: 3.0 +/- 1.4

p = 0.01), and semantic verbal fluency test (RES group: 13.6 +/- 3.3

control group: 16.9 +/- 4.3

p = 0.04). Conclusion: In summary, the mean depression scale score in the group with residual excessive sleepiness was significantly higher than that in the control group. Patients with residual excessive sleepiness showed impairment of executive functions but no impairments in other cognitive domains. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Obstructive sleep apnea
Residual excessive sleepiness
Cognitive functions
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2016
Published in Sleep Medicine. Amsterdam, v. 26, p. 6-11, 2016.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 6-11
Access rights Closed access
Type Article
Web of Science ID WOS:000390720900002

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