Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

Author Peres, Paulo Alberto Autor UNIFESP Google Scholar
Bernardelli, Graziella França Autor UNIFESP Google Scholar
Mendes, Cássia Claudino Autor UNIFESP Google Scholar
Fischer, Sven C P M Autor UNIFESP Google Scholar
Servantes, Denise Maria Autor UNIFESP Google Scholar
Medeiros, Wladimir Musetti Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Marfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.
Keywords Exercise
Aortic elasticity
Pulse wave velocity
Marfan syndrome
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-04-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 4, p. 397-402, 2010.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 397-402
Origin http://dx.doi.org/10.1590/S0100-879X2010007500021
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000276670300011
SciELO ID S0100-879X2010000400011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/5691

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