Sleep disorders in Machado-Joseph disease

Sleep disorders in Machado-Joseph disease

Author Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Braga-Neto, Pedro Google Scholar
Martinez, Alberto R. M. Google Scholar
Martins Junior, Carlos R. Google Scholar
Rezende Filho, Flavio Moura Autor UNIFESP Google Scholar
Sobreira-Neto, Manoel A. Google Scholar
Prado, Lucila Bizari Fernandes do Autor UNIFESP Google Scholar
Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Franca Junior, Marcondes C. Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Abstract Purpose of reviewThis article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD).Recent findingsPathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders.SummarySleep disorders are frequent in MJD, and include restless legs syndrome, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, insomnia, sleep apnea, periodic limb movements during sleep, parasomnia, and others. Pathophysiological mechanisms related to sleep disorders in Machado-Joseph are complex and poorly understood. Considering that sleep complaints are a treatable condition, recognizing sleep disorders in MJD is relevant.
Keywords Machado-Joseph disease
nonmotor symptoms
sleep disorders
spinocerebellar ataxia type 3
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Date 2016
Published in Current Opinion In Psychiatry. Philadelphia, v. 29, n. 6, p. 402-408, 2016.
ISSN 0951-7367 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 402-408
Access rights Closed access
Type Article
Web of Science ID WOS:000385508700014

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