Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions

Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions

Author Caris, Aline Venticinque Autor UNIFESP Google Scholar
Silva, Edgar Tavares da Autor UNIFESP Google Scholar
Santos, Samile Amorim dos Autor UNIFESP Google Scholar
Lira, Fabio Santos Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Abstract Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditions

normoxia, hypoxia and hypoxia + carbohydrate supplementation. Blood samples were collected at rest, at the end of exercise and after 60 min of recovery. To evaluate hypoxia + carbohydrate supplementation, volunteers received a solution of 6% carbohydrate (maltodextrin) or a placebo (strawberry-flavored Crystal Light (R)

Kraft Foods, Northfield, IL, USA) every 20 min during exercise and recovery. Statistical analyses comprised analysis of variance, with a one-way ANOVA followed by the Tukey post hoc test with a significance level of p < 0.05. Results: Under normoxic and hypoxic conditions, there was a significant increase in the concentration of IL-6 after exercise and after recovery compared to at rest (p < 0.05), while in the hypoxia + carbohydrate group, there was a significant increase in the concentration of IL-6 and TNF-alpha after exercise compared to at rest (p < 0.05). Furthermore, under this condition, TNF-alpha, IL-2 and the balance of IL-2/IL-4 were increased after recovery compared to at rest (p < 0.05). Conclusion: We conclude that carbohydrate supplementation modified the IL-6 and TNF-alpha serum concentrations and shifted the IL-2/IL-4 balance towards Th1 in response without glycemic, glutaminemia and cell damage effects.
Keywords supplementation
carbohydrate
hypoxia
exercise
immune system
IL-2/IL-4
xmlui.dri2xhtml.METS-1.0.item-coverage Basel
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Grant number FAPESP: 2013/01324-4
Date 2016
Published in Nutrients. Basel, v. 8, n. 11, p. -, 2016.
ISSN 2072-6643 (Sherpa/Romeo, impact factor)
Publisher Mdpi Ag
Extent -
Origin http://dx.doi.org/10.3390/nu8110706
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000388666400041
URI https://repositorio.unifesp.br/handle/11600/56823

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