Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars

Observational retrospective study evaluating the effects of oral isotretinoin in keloids and hypertrophic scars

Author Guadanhim, Lilia Ramos dos Santos Autor UNIFESP Google Scholar
Goncalves, Rubens Guilherme Autor UNIFESP Google Scholar
Bagatin, Edileia Autor UNIFESP Google Scholar
Abstract Background Acne vulgaris is a chronic inflammatory disease characterized by noninflammatory and inflammatory lesions that can cause scarring. Oral isotretinoin is the current recommended treatment for moderate and severe cases

however, there are reports of possible influences on the healing process of the skin, leading to an increase in the risk for hypertrophic scars and keloids. This hypothesis, although unproven, represents a contraindication to the treatment of acne scars during the 6-12 months after the cessation of isotretinoin. Objectives The aim of this study was to investigate the prevalences of hypertrophic scars and keloids in acne patients treated with oral isotretinoin. Methods Three data collection strategies were used: (i) clinical examination of patients with acne vulgaris, exposed or unexposed to oral isotretinoin, focusing on the occurrence of hypertrophic scars and/or keloids

(ii) telephone interviews of patients using oral isotretinoin to treat acne vulgaris on the occurrence or worsening of keloids

and (iii) clinical examination of patients with previous use of oral isotretinoin followed at a specific keloid treatment clinic. Results The resulting data showed no differences in wound healing. Conclusions These findings may indicate that the occurrence of hypertrophic scars or keloids in patients using oral isotretinoin is an undesirable event arising from an individual response and may be related to inflammatory acne evolution.
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2016
Published in International Journal Of Dermatology. Hoboken, v. 55, n. 11, p. 1255-1258, 2016.
ISSN 0011-9059 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1255-1258
Origin http://dx.doi.org/10.1111/ijd.13317
Access rights Closed access
Type Article
Web of Science ID WOS:000385763500025
URI https://repositorio.unifesp.br/handle/11600/56810

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