Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

Alternative title Polimorfismo do receptor Fc gama IIIa não está associado à susceptibilidade ao lúpus eritematoso sistêmico em pacientes brasileiros
Author Grecco, Marcelle Autor UNIFESP Google Scholar
Santos, Viviane Cardoso dos Autor UNIFESP Google Scholar
Pereira, Kaline Medeiros Costa Autor UNIFESP Google Scholar
Andrade, Luiz Eduardo Coelho Autor UNIFESP Google Scholar
Silva, Neusa Pereira da Autor UNIFESP Google Scholar
Abstract We evaluated the possible association between FCGR3AV/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerise chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease. (C) 2016 Published by Elsevier Editora Ltda.

Avaliou-se a possível associação entre o polimorfismo FCGR3A V/F (158) e a suscetibilidade e o fenótipo clínico do lúpus eritematoso sistêmico (LES) em 305 pacientes com LES admitidos sequencialmente e 300 controles saudáveis da Região Sudeste do Brasil por reação em cadeia da polimerase alelo-específica. Os resultados do presente estudo mostraram não haver associação entre os alelos FCGR3A 158 V/F e a suscetibilidade ao LES nessa série de pacientes, ainda que o genótipo heterozigoto tenha sido fortemente associado à doença.
Keywords Systemic lupus erythematosus
Fc gamma receptor IIIa
Single nucleotide polymorphism
Gene polymorphism
Immunogenetics
Lúpus eritematoso sistêmico
Receptor Fc gama IIIa
Polimorfismo de nucleotídeo único
Polimorfismo genético
Imunogenética
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Portuguese
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2008/50213-2
CNPq: 476356/2008-3
Date 2016
Published in Revista Brasileira De Reumatologia. New York, v. 56, n. 6, p. 515-520, 2016.
ISSN 0482-5004 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 515-520
Origin http://dx.doi.org/10.1016/j.rbre.2016.07.013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000389548800009
SciELO ID S0482-50042016000600515 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56807

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