Comparison of Optical Coherence Tomography Angiography and Fluorescein Angiography for the Identification of Retinal Vascular Changes in Eyes With Diabetic Macular Edema

Comparison of Optical Coherence Tomography Angiography and Fluorescein Angiography for the Identification of Retinal Vascular Changes in Eyes With Diabetic Macular Edema

Author Peres, Murilo Bertazzo Autor UNIFESP Google Scholar
Kato, Renata Tiemi Autor UNIFESP Google Scholar
Kniggendorf, Vinicius Ferreira Autor UNIFESP Google Scholar
Cole, Emily D. Google Scholar
Onal, Sumru Google Scholar
Torres, Elmar Autor UNIFESP Google Scholar
Louzada, Ricardo Google Scholar
Belfort, Rubens Junior Autor UNIFESP Google Scholar
Duker, Jay S. Google Scholar
Novais, Eduardo Amorim Autor UNIFESP Google Scholar
Regatieri, Caio Vinicius Saito Autor UNIFESP Google Scholar
Abstract BACKGROUND AND OBJECTIVE: To compare the visualization of microaneurysms (MA) and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) versus fluorescein angiography (FA) in patients with diabetic macular edema (DME). PATIENTS AND METHODS: Patients were prospectively recruited for same-day imaging on spectral-domain OCTA and FA. OCTA images were automatically segmented into superficial (sOCTA) and deep (dOCTA) capillary plexuses. The number of visible MAs and the FAZ area were compared between the two imaging modalities. RESULTS: Nineteen eyes of 10 patients were included. There was a statistically significant difference between MA counts for FA, sOCTA, and dOCTA (P = .002), and median MA counts were 14.5 (range: 2-43), 9.75 (range: 0-37.5), and 22.5 (range: 5.5-46.5), respectively. dOCTA showed significantly more MAs than sOCTA (P < .001). Although not significant statistically, dOCTA revealed more MAs than FA (P = .06). There was a statistically significant difference between FAZ area for FA, sOCTA, and dOCTA (P = .046), and median FAZ areas were 0.444 (range: 0.1-0.689), 0.224 (range: 0.335-0.806), and 0.345 (range: 0.106-0.881), respectively. FA showed a significantly larger FAZ area than sOCTA (P = .04). CONCLUSIONS: Deep plexus OCTA can better identify microaneurysms compared to either sOCTA or FA. The FAZ area appears larger on FA in contrast to OCTA of both plexuses.
xmlui.dri2xhtml.METS-1.0.item-coverage Thorofare
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2016
Published in Ophthalmic Surgery Lasers & Imaging Retina. Thorofare, v. 47, n. 11, p. 1013-1019, 2016.
ISSN 2325-8160 (Sherpa/Romeo, impact factor)
Publisher Slack Inc
Extent 1013-1019
Origin http://dx.doi.org/10.3928/23258160-20161031-05
Access rights Closed access
Type Article
Web of Science ID WOS:000393104400005
URI https://repositorio.unifesp.br/handle/11600/56753

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