Experimental study of inflammatory response and collagen morphometry with different types of meshes

Experimental study of inflammatory response and collagen morphometry with different types of meshes

Author Maeda, Carlos Toshinori Autor UNIFESP Google Scholar
Artigiani Neto, Ricardo Autor UNIFESP Google Scholar
Lopes Filho, Gaspar de Jesus Autor UNIFESP Google Scholar
Linhares, Marcelo Moura Autor UNIFESP Google Scholar
Abstract To compare an inflammation score and collagen morphometry after incisional hernia repair with four different meshes at two time points. Four types of mesh were used to repair an abdominal wall incisional defect in Wistar rats: high-density polypropylene (HW/PP)

low-density polypropylene (LW/PP)

polypropylene mesh encapsulated with polydioxanone coated with oxidized cellulose (PP/CE)

and expanded polytetrafluoroethylene (ePTFE). An inflammation score based on histological analysis and collagen morphometry was performed after 7 and 28 days after operation (POD). Compared to LW/PP group at 7 POD, HW/PP group had lower (p = 0.014) and PP/CE group had higher inflammation scores (p = 0.001). At 28 POD, higher scores were seen in all the other groups compared to the LW/PP group (HW/PP, p = 0.046

PP/CE, p < 0.001

ePTFE, p = 0.027). Comparing groups individually at 7 and 28 PODs, all demonstrated lower inflammation score values at 28 POD (HW/PP, p < 0.001

LW/PP, p < 0.001

PP/CE, p = 0.002

ePTFE, p = 0.001). At 7 POD, higher amounts of collagen were detected in ePTFE compared to HW/PP (p < 0.001) and LW/PP (p = 0.004) and in PPCE group compared to HW/PP (p = 0.022). At 28 POD, no statistically significant difference was found. Comparing groups individually at 7 and 28 PODs, HW/PP and LW/PP showed larger amounts of collagen at the 28th POD, without any statistically significant differences for the PP/CE and ePTFE groups. Inflammation scores decreased in all groups at 28 POD. Collagen deposition was higher for non-composite meshes at 28 POD.
Keywords Incisional hernia
Polypropylene
Inflammation
Collagen
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2016
Published in Hernia. New York, v. 20, n. 6, p. 859-867, 2016.
ISSN 1265-4906 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 859-867
Origin http://dx.doi.org/10.1007/s10029-016-1513-7
Access rights Closed access
Type Article
Web of Science ID WOS:000388186100012
URI https://repositorio.unifesp.br/handle/11600/56670

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