Neuropsychiatric Lupus in clinical practice

Neuropsychiatric Lupus in clinical practice

Author Alessi, Helena Autor UNIFESP Google Scholar
Dutra, Livia Almeida Autor UNIFESP Google Scholar
Braga-Neto, Pedro Google Scholar
Pedroso, Jose Luiz Autor UNIFESP Google Scholar
Toso, Fabio Fieni Autor UNIFESP Google Scholar
Kayser, Cristiane Autor UNIFESP Google Scholar
Barsottini, Orlando Graziani Povoas Autor UNIFESP Google Scholar
Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations. This article reviews major neuropsychiatric manifestations in patients with SLE and discusses their clinical features, radiological findings and treatment options.
Keywords systemic lupus erythematosus
lupus vasculitis
central nervous system
seizures
myelitis
autoimmune diseases
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2015/08833-7
Date 2016
Published in Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 12, p. 1021-1030, 2016.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos Neuro- Psiquiatria
Extent 1021-1030
Origin http://dx.doi.org/10.1590/0004-282X20160150
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000391350400013
SciELO ID S0004-282X2016001201021 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56613

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