Toward Quantitative Optical Coherence Tomography Angiography Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

Toward Quantitative Optical Coherence Tomography Angiography Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

Author Ploner, Stefan B. Google Scholar
Moult, Eric M. Google Scholar
Choi, Woojhon Google Scholar
Waheed, Nadia K. Google Scholar
Lee, Byungkun Google Scholar
Novais, Eduardo Amorim Autor UNIFESP Google Scholar
Cole, Emily D. Google Scholar
Potsaid, Benjamin Google Scholar
Husvogt, Lennart Google Scholar
Schottenhamml, Julia Google Scholar
Maier, Andreas Google Scholar
Rosenfeld, Philip J. Google Scholar
Duker, Jay S. Google Scholar
Hornegger, Joachim Google Scholar
Fujimoto, James G. Google Scholar
Abstract Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Methods: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. Results: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. Conclusion: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
Keywords ocular blood flow
variable interscan time analysis (VISTA)
optical coherence tomography (OCT)
optical coherence tomography angiography (OCTA)
age-related macular degeneration
nascent geographic atrophy
choroidal neovascularization
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Macula Vision Research Foundation, New York
Champalimaud Foundation
National Institutes of Health
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Carl Zeiss Meditec
Carl Zeiss Meditec, Inc.
Grant number NIH: NIH R01-EY011289-29
NIH: R44-EY022864
NIH: R01-CA075289-16
NIH: FA9550-15-1-0473
NIH: FA9550-12-1-0499
Date 2016
Published in Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 36, n. 12, p. S118-S126, 2016.
ISSN 0275-004X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent S118-S126
Access rights Closed access
Type Article
Web of Science ID WOS:000391946700013

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