Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics

Association of Exercise Training with Tobacco Smoking Prevents Fibrosis but has Adverse Impact on Myocardial Mechanics

Author Reis Junior, Dermeval Autor UNIFESP Google Scholar
Antonio, Ednei Luiz Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
de Oliveira, Helenita Antonia Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Serra, Andrey Jorge Autor UNIFESP Google Scholar
Abstract Introduction: There was no data for cardiac repercussion of exercise training associated with tobacco smoking. This issue is interesting because some smoking people can be enrolled in an exercise-training program. Thus, we evaluated swimming training effects on the function and structural myocardial in rats exposed to tobacco smoking. Methods: Male Wistar rats were assigned to one of four groups: C, untrained rats without exposure to tobacco smoking

E, exercised rats without exposure to tobacco smoking

CS, untrained rats exposed to tobacco smoking

ECS, exercised rats exposed to tobacco smoking. Rats swam five times a week twice daily (60 min per session) for 8 weeks. Before each bout exercise, rats breathed smoke from 20 cigarettes for 60 min. Twenty-four hours after the last day of the protocol, papillary muscles were isolated for in vitro analysis of myocardial mechanics. The myocardial mass and nuclear cardiomyocyte volume were used as hypertrophy markers, and collagen content was determined by picrosirius red staining. Results: There was a well-pronounced myocardial hypertrophic effect for two interventions. The exercise blunted myocardial collagen increases induced by tobacco smoking. However, exercise and tobacco-smoking association was deleterious to myocardial performance. Thereby, in vitro experiments with papillary muscles contracting in isometric showed impairment myocardial inotropism in exercised rats exposed to tobacco smoking. Conclusions: This work presents novel findings on the role of exercise training on cardiac remodeling induced by tobacco smoking. Although exercise has mitigated tissue fibrosis, their association with tobacco smoking exacerbated hypertrophy and in vitro myocardial dysfunction. Implications: This is first study to show that the association of an aerobic exercise training with tobacco smoking intensifies the phenotype of pathological cardiac hypertrophy. Therefore, the combination of interventions resulted in exacerbated myocardial hypertrophy and contractility dysfunction. These findings have significant clinical implication because some smoking people can be enrolled in an exercise-training program.
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 09/54225-8
FAPESP: 2015/11028-9
CNPq: 478740/2011-5
Date 2016
Published in Nicotine & Tobacco Research. Oxford, v. 18, n. 12, p. 2268-2272, 2016.
ISSN 1462-2203 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 2268-2272
Origin http://dx.doi.org/10.1093/ntr/ntw180
Access rights Closed access
Type Article
Web of Science ID WOS:000393193300013
URI https://repositorio.unifesp.br/handle/11600/56590

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