Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial

Low-dose oral isotretinoin for moderate to severe seborrhea and seborrheic dermatitis: a randomized comparative trial

Author Kamamoto, Cristhine de Souza Leao Autor UNIFESP Google Scholar
Sanudo, Adriana Autor UNIFESP Google Scholar
Hassun, Karime Marques Autor UNIFESP Google Scholar
Bagatin, Edileia Autor UNIFESP Google Scholar
Abstract BackgroundThe efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies. ObjectivesThis study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face. MethodsA randomized, comparative clinical trial, using two groups, was conducted over 6 months. Patients in Group ISO were treated with isotretinoin 10 mg every other day. In Group X, patients received antiseborrheic topical treatment. Patient opinion, investigator assessment, scalp pruritus, sebum production, and quality of life (QoL) comprised the efficacy outcomes. ResultsThe intention-to-treat population comprised a total of 45 patients with mean standard deviation ages of 28.7 +/- 5.8 years in Group ISO and 29.8 +/- 6.5 years in Group X. The rate of sebum production significantly decreased in Group ISO. Patient opinion, investigator, and QoL assessments improved in both groups. ConclusionsLow-dose oral isotretinoin can be a therapeutic modality for moderate to severe seborrhea and seborrheic dermatitis.
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2010/51049-1
Date 2017
Published in International Journal Of Dermatology. Hoboken, v. 56, n. 1, p. 80-85, 2017.
ISSN 0011-9059 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 80-85
Origin http://dx.doi.org/10.1111/ijd.13408
Access rights Closed access
Type Article
Web of Science ID WOS:000390646200021
URI https://repositorio.unifesp.br/handle/11600/56517

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account