Leptin as a cardiovascular risk marker in metabolically healthy obese Hyperleptinemia in metabolically healthy obese

Leptin as a cardiovascular risk marker in metabolically healthy obese Hyperleptinemia in metabolically healthy obese

Author Jamar, Giovana Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Cesar, Helena de Cassia Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Bandoni, Daniel Henrique Autor UNIFESP Google Scholar
Pisani, Luciana Pellegrini Autor UNIFESP Google Scholar
Abstract Adipokines contribute to the inflammatory process which can lead to obesity-associated cardiometabolic complications. Metabolically healthy obese individuals seem to be protected or more resistant to develop these complications and it is intriguing why some individuals develop comorbidities and others do not. Thus, we questioned whether the differences between metabolically healthy and unhealthy obese relied on the alterations in metabolic profile, characterized by serum leptin and adiponectin. A total of 142 obese adults were divided into 2 groups - metabolically healthy obese (MHO) or unhealthy obese (MUO) - and they were evaluated for anthropometric measures, body composition, blood pressure, dietary intakes and plasma levels of leptin and adiponectin. Leptin/adiponectin ratio (L/A) was calculated. Age, BMI and blood pressure were higher in the MUO. No differences in anthropometric measurements, body composition, dietary intake and dietary quality were observed between groups. Leptin were significantly higher in the MUO (53.07 +/- 34.56 versus 36.27 +/- 24.02 ng/ml in the MHO, r < 0.04). The logistic regression analysis demonstrated that leptin was an important factor associated with not being healthy, independent of age, body weight and BMI. There were no differences between groups for adiponectin and L/A. Leptin correlated positively with body weight (r = 0.25, r < 0.05), BMI (r = 0.38, r < 0.05) and BF (r = -0.74, r < 0.05), and negatively with FFM (r = 0.74, r < 0.05). Our findings suggest that leptin is an important cardiovascular disease marker to obese population and can contribute to evaluate metabolic risks in these individuals. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords Metabolic obesity
Healthy
Adipokines
Hyperleptinemia
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 11/51723-7
CNPq: 471108/2011-1
Date 2017
Published in Appetite. London, v. 108, p. 477-482, 2017.
ISSN 0195-6663 (Sherpa/Romeo, impact factor)
Publisher Academic Press Ltd- Elsevier Science Ltd
Extent 477-482
Origin http://dx.doi.org/10.1016/j.appet.2016.11.013
Access rights Closed access
Type Article
Web of Science ID WOS:000390622000056
URI https://repositorio.unifesp.br/handle/11600/56510

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