Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence

Patients with sickle cell disease are frequently excluded from the benefits of transcranial doppler screening for the risk of stroke despite extensive and compelling evidence

Author Rodrigues, Daniela Laranja Gomes Autor UNIFESP Google Scholar
Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Campos, Rejane de Souza Macedo Autor UNIFESP Google Scholar
Braga, Josefina Aparecida Pellegrini Autor UNIFESP Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Abstract Transcranial doppler (TCD) is a strategic component of primary stroke prevention in children with sickle cell disease (SCD). This study was conducted to examine the TCD characteristics of children with SCD in nine different medical centers in Brazil. Methods: Transcranial doppler was performed in accordance with the Stroke Prevention Trial in Sickle Cell Anemia Protocol. Results: Of the 396 patients, 69.5% had homozygous SS hemoglobin. The TCD result was abnormal in 4.8%, conditional in 12.6%, inadequate in 4.3% and abnormally low in 1% of patients. The highest mean flow velocities were 121 +/- 23.83cm/s and 124 +/- 27.21cm/s in the left and right middle cerebral artery respectively. A total of 28.8% patients (mean age 9.19 +/- 5.92 years) were evaluated with TCD for the first time. Conclusions: The SCD patients were evaluated with TCD at an older age, representing an important missed opportunity for stroke prevention. Since TCD screening in patients with SCD is important to detect those at high risk for stroke, it is recommended that this screening should be made more readily available.
Keywords sickle cell disease
ultrasonography
doppler
transcranial
stroke
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Date 2017
Published in Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 1, p. 15-19, 2017.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos Neuro- Psiquiatria
Extent 15-19
Origin http://dx.doi.org/10.1590/0004-282X20160175
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000393268400004
SciELO ID S0004-282X2017000100015 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56458

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