Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia A controlled clinical trial

Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia A controlled clinical trial

Author Machado, Paola Autor UNIFESP Google Scholar
Caris, Aline Venticinque Autor UNIFESP Google Scholar
Santos, Samile Amorim dos Autor UNIFESP Google Scholar
Silva, Edgar Tavares da Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Abstract Background: Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin concentration in normobaric hypoxia. Methods: Nine healthy male volunteers exercised on a treadmill for 60 minutes at an intensity of 50% VO2peak in normoxic or hypoxic conditions (4200 m). Blood was collected at rest, immediately after exercise and 1 hour after exercise to evaluate serum endotoxin levels. Results: Under hypoxic exercise conditions, SaO(2)% saturation was lower after exercise compared with resting levels (P<0.05) and returned to the resting level during recovery in normoxia (P<0.05). Endotoxin concentration increased after exercise in hypoxia (P<0.05)

it remained high 1hour after exercise in hypoxia compared with normoxia (P<0.05) and was higher after exercise and recovery compared with resting levels (P<0.05). HR was higher during exercise in relation basal in both conditions (P<0.05) and RPR increase after 60minutes in comparison to 20minutes in hypoxia (P<0.05). Conclusion: Moderate exercise performed in hypoxia equivalent to 4200 m increased endotoxin plasma concentration after exercise. One hour of rest in normoxic conditions was insufficient for the recovery of circulating endotoxins.
Keywords enterocytes
high altitude
intestinal barrier
moderate exercise
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associação Fundo de Incentivo à Psicofarmacologia (AFIP)
Grant number FAPESP: 2013/01324-4
Date 2017
Published in Medicine. Philadelphia, v. 96, n. 4, p. -, 2017.
ISSN 0025-7974 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent -
Access rights Closed access
Type Article
Web of Science ID WOS:000393717200005

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