Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Author Siviero-Miachon, Adriana Aparecida Autor UNIFESP Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Lee, Maria Lúcia de Martino Autor UNIFESP Google Scholar
Calixto, Antonio Ramos Google Scholar
Geloneze, Bruno Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Guerra-Junior, Gil Google Scholar
Abstract Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect of body composition and adipokines on bone mass in survivors of acute lymphocytic leukemia. This was a cross-sectional study of 56 survivors aged between 15 and 24 years, 44.6 % of whom received cranial radiotherapy (18-24 Gy), assessed according to body fat, lean mass, and bone mineral density (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, and adipokines by a multiple regression analysis. Both lumbar spine L-1-L-4 (trabecular bone) and total body (cortical bone) bone mineral density were positively correlated with visfatin (p < 0.050). Lean mass index was positively correlated, while waist-to-height ratio was negatively correlated with cortical bone (p < 0.010). Low bone mineral density for chronological age was detected in 5.4 % of patients in total body, and 8.9 % at the lumbar spine. In survivors of acute lymphocytic leukemia, visfatin may play an important role in the complex relationship between body composition and bone. At present, visfatin may represent a model for further study of bone metabolism, and could possibly explain the unknown mechanisms linking bone metabolism and cancer.
Keywords Precursor cell lymphoblastic leukemia-lymphoma/complications
Body composition
Metabolic syndrome X
Bone density
xmlui.dri2xhtml.METS-1.0.item-coverage Tokyo
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/06162-9
Date 2017
Published in Journal Of Bone And Mineral Metabolism. Tokyo, v. 35, n. 1, p. 73-82, 2017.
ISSN 0914-8779 (Sherpa/Romeo, impact factor)
Publisher Springer Japan Kk
Extent 73-82
Access rights Closed access
Type Article
Web of Science ID WOS:000394243900010

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