Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample

Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample

Author Taylor, Sylvia Google Scholar
Lopez, Pio Google Scholar
Weckx, Lily Autor UNIFESP Google Scholar
Borja-Tabora, Charissa Google Scholar
Ulloa-Gutierrez, Rolando Google Scholar
Lazcano-Ponce, Eduardo Google Scholar
Kerdpanich, Angkool Google Scholar
Rodriguez Weber, Miguel Angel Google Scholar
Mascarenas de Los Santos, Abiel Google Scholar
Tinoco, Juan-Carlos Google Scholar
Safadi, Marco Aurelio P. Google Scholar
Lim, Fong Seng Google Scholar
Hernandez-de Mezerville, Marcela Google Scholar
Faingezicht, Idis Google Scholar
Cruz-Valdez, Aurelio Google Scholar
Feng, Yang Google Scholar
Li, Ping Google Scholar
Durviaux, Serge Google Scholar
Haars, Gerco Google Scholar
Roy-Ghanta, Sumita Google Scholar
Vaughn, David W. Google Scholar
Nolan, Terry Google Scholar
Abstract Background: Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed. Methods: The epidemiology of respiratory viruses among healthy children (6 months to < 10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs. Results: 6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medicallyattended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/ enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza). Conclusions: Active surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children. (C) 2016 Published by Elsevier Ltd on behalf of The British Infection Association.
Keywords Active surveillance
Influenza-like illness
Healthy children
Respiratory viruses
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor GlaxoSmithKline Biologicals S.A
Date 2017
Published in Journal Of Infection. London, v. 74, n. 1, p. 29-41, 2017.
ISSN 0163-4453 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 29-41
Access rights Closed access
Type Article
Web of Science ID WOS:000396367000004

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