Recent advances in lipidomics: Analytical and clinical perspectives

Recent advances in lipidomics: Analytical and clinical perspectives

Author Sethi, Sumit Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Lipidomics or lipid-profiling is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. The extent of information in the genomic and proteomic fields is greater than that in the lipidomics field, because of the complex nature of lipids and the limitations of tools for analysis. Modern technological advances in mass spectrometry and chromatography have greatly improved the developments and applications of metabolic profiling of diverse lipids in complex biological samples. Lipidomics will not only provide insights into the specific functions of lipid species in health and disease, but will also identify potential biomarkers for establishing preventive or therapeutic programs for human diseases. In this review, emphasis is given to the current advances in lipidomics technologies and their applications in disease biomarker discovery, and its clinical application. The application oflipidomics in clinical studies may provide new insights into lipid profiling and pathophysiological mechanisms. We also discuss the lipidomics for the future perspectives and their potential problems. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Biomarker
Lipid
Lipidomics
Liquid chromatography
Mass spectrometry
Metabolomics
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2017
Published in Prostaglandins & Other Lipid Mediators. New York, v. 128, p. 8-16, 2017.
ISSN 1098-8823 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 8-16
Origin http://dx.doi.org/10.1016/j.prostaglandins.2016.12.002
Access rights Closed access
Type Article
Web of Science ID WOS:000397371100002
URI https://repositorio.unifesp.br/handle/11600/56361

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