Association between asthma and female sex hormones

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dc.contributor.author de Carvalho Baldacara, Raquel Prudente
dc.contributor.author Silva, Ivaldo [UNIFESP]
dc.date.accessioned 2020-07-31T12:46:45Z
dc.date.available 2020-07-31T12:46:45Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1590/1516-3180.2016.011827016
dc.identifier.citation Sao Paulo Medical Journal. Sao Paulo, v. 135, n. 1, p. 4-14, 2017.
dc.identifier.issn 1516-3180
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56339
dc.description.abstract CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de Sao Paulo (Unifesp). METHODS: We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS: The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS: The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-alpha production, interferon-gamma expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted. en
dc.format.extent 4-14
dc.language.iso eng
dc.publisher Associacao Paulista Medicina
dc.relation.ispartof Sao Paulo Medical Journal
dc.rights Acesso aberto
dc.subject Asthma en
dc.subject Gonadal steroid hormones en
dc.subject Women en
dc.subject Contraceptives, oral en
dc.subject Cytokines en
dc.title Association between asthma and female sex hormones en
dc.type Artigo
dc.description.affiliation UFT, Med, Palmas, TO, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Gynecology, Universidade Federal do São Paulo (SP), Brazil
dc.identifier.file S1516-31802017000100004.pdf
dc.identifier.scielo S1516-31802017000100004
dc.identifier.doi 10.1590/1516-3180.2016.011827016
dc.description.source Web of Science
dc.identifier.wos WOS:000398127000002
dc.coverage Sao Paulo
dc.citation.volume 135
dc.citation.issue 1



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