Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation

Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation

Author Lima, Camila Bruna de Autor UNIFESP Google Scholar
Cordeiro, Fernanda Bertuccez Autor UNIFESP Google Scholar
Camargo, Mariana Autor UNIFESP Google Scholar
Zylbersztejn, Daniel Suslik Autor UNIFESP Google Scholar
Cedenho, Agnaldo Pereira Autor UNIFESP Google Scholar
Bertolla, Ricardo Pimenta Autor UNIFESP Google Scholar
Lo Turco, Edson Guimaraes Autor UNIFESP Google Scholar
Abstract This observational study aimed to establishing a relationship between lipid peroxidation and endometriosis in women undergoing controlled ovarian hyperstimulation. A total of 79 women were divided into two groups: (i) controls (tubal or male factor)

and (ii) endometriosis (stages III/IV). The endometriosis diagnosis was confirmed by videolaparoscopy and the controlled ovarian stimulation protocol was similar to all patients. Follicular fluid (FF) lipid peroxidation levels were determined through the quantification of malondialdehyde. Statistical analysis was performed using parametric and non-parametric tests, logistic regression was performed to estimate the chance of achieving a pregnancy in each group and a moving average was calculated for the endometriosis group. Peroxidation levels in the endometriosis group were significantly higher when compared to controls. The moving average showed a decrease of MDA levels in the endometriosis group with increasing female age. Moreover, women with endometriosis who were under 33 years of age were 4.3 times more likely to achieve a pregnancy than women above that age. In conclusion, endometriosis is associated with increased FF oxidative stress (OS) in patients undergoing in vitro fertilization (IVF). Also, increasing age is associated with a decrease in severity of the oxidative status, but a decreased chance of pregnancy.
Keywords Endometriosis
oxidative stress
follicular fluid
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2017
Published in Human Fertility. Abingdon, v. 20, n. 1, p. 48-54, 2017.
ISSN 1464-7273 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 48-54
Access rights Closed access
Type Article
Web of Science ID WOS:000398185900009

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