Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Anti-Cancer Phytometabolites Targeting Cancer Stem Cells

Author Torquato, Heron Fernandes Vieira Autor UNIFESP Google Scholar
Goettert, Marcia I. Google Scholar
Justo, Giselle Zenker Autor UNIFESP Google Scholar
Paredes-Gamero, Edgar Julian Autor UNIFESP Google Scholar
Abstract Medicinal plants are a plentiful source of bioactive molecules with much structural diversity. In cancer treatment, molecules obtained from plants represent an attractive alternative to other treatments because several plant-derived compounds have exhibited lower toxicity and higher selectivity against cancer cells. In this review, we focus on the possible application of bioactive molecules obtained from plants against more primitive cell populations in cancers, cancer stem cells. Cancer stem cells are present in several kinds of tumors and are responsible for recurrences and metastases. Common anticancer drugs exhibit lower effectiveness against cancer stem cells because of their biological features. However, recently discovered natural phytometabolites exert cytotoxic effects on this rare population of cells in cancers. Therefore, this review presents the latest research on promising compounds from plants that can act as antitumor drugs and that mainly affect stem cell populations in cancers.
Keywords Natural compounds
Cancer stem cells
ABC transporters
Wnt
Notch
Hedgehog
NF-kappa B
xmlui.dri2xhtml.METS-1.0.item-coverage Sharjah
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2013/09068-7
CNPq: 473797/2013
Date 2017
Published in Current Genomics. Sharjah, v. 18, n. 2, p. 156-174, 2017.
ISSN 1389-2029 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 156-174
Origin http://dx.doi.org/10.2174/1389202917666160803162309
Access rights Closed access
Type Article
Web of Science ID WOS:000400683600004
URI https://repositorio.unifesp.br/handle/11600/56310

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