Identification of infants and preschool children at risk for asthma: predictive scores and biomarkers

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dc.contributor.author Wandalsen, Gustavo Falbo [UNIFESP]
dc.contributor.author Solé, Dirceu [UNIFESP]
dc.contributor.author Bacharier, Leonard B.
dc.date.accessioned 2020-07-22T13:23:21Z
dc.date.available 2020-07-22T13:23:21Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1097/ACI.0000000000000240
dc.identifier.citation Current Opinion In Allergy And Clinical Immunology. Philadelphia, v. 16, n. 2, p. 120-126, 2016.
dc.identifier.issn 1528-4050
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56197
dc.description.abstract Purpose of reviewPredictive asthma scores and biomarkers are important tools that help many physicians in the identification of infants and preschool children at high risk for asthma. Our objective was to review recent data regarding this subject.Recent findingsRecently, two new predictive asthma scores were developed with some innovative features, such as the definition of scales of asthma risk. In a systematic review, 12 asthma-predictive models were identified with heterogeneous performance. Prospective studies have shown that elevated fractional concentration of nitric oxide (FeNO) is a strong risk factor for latter asthma among early wheezers, and a predictive asthma score with FeNO values has been proposed. Plasma cytokines and exhaled volatile organic compounds were also identified as potential asthma predictors.SummaryPredictive scores are simple, practical, and inexpensive tools to identify children at high risk for asthma at school age. Whereas some scores are better at identifying asthmatic children, others are better at excluding the diagnosis of asthma. Although promising, clear evidence for FeNO as a robust asthma predictor in comparison to clinical scores is still lacking. Specific IgE and eosinophil counts remain the most consistent biomarkers for the identification of children at risk for asthma, and further studies are necessary to clarify the role of other biomarkers. en
dc.description.sponsorship CNPq
dc.description.sponsorship National Institutes of Health
dc.format.extent 120-126
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Current Opinion In Allergy And Clinical Immunology
dc.rights Acesso restrito
dc.subject asthma en
dc.subject biomarkers en
dc.subject children en
dc.subject exhaled nitric oxide en
dc.subject predictive scores en
dc.title Identification of infants and preschool children at risk for asthma: predictive scores and biomarkers en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliation Washington Univ, Sch Med, St Louis, MO USA
dc.description.affiliation St Louis Childrens Hosp, St Louis, MO 63178 USA
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Sao Paulo, Brazil
dc.identifier.doi 10.1097/ACI.0000000000000240
dc.description.source Web of Science
dc.identifier.wos WOS:000371825500007
dc.coverage Philadelphia
dc.citation.volume 16
dc.citation.issue 2



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